感染症と治療ジャーナル

抽象的な

A Five Years Tuberculosis Treatment Outcome at Kolla Diba Health Center, Dembia District, Northwest Ethiopia: A Retrospective Cross-sectional Analysis

Mucheye G. Beza, Moges T. Wubie, Mulat D. Teferi, Yenework S. Getahun, Sisay M. Bogale and Selam B. Tefera

Multiple studies of tuberculosis treatment have indicated that effective treatment of tuberculosis requires adherence to a minimum of 6 months treatment with multiple drugs. At Kolla Diba Health Center, standardized tuberculosis prevention and control programme, integrating Directly Observed Treatment, Short Course (DOTS) strategy started in 1996. Treatment outcome is an important indicator of tuberculosis control programs as the World Health Organization suggested. We, therefore, carried out this study to investigate the outcome of tuberculosis treatment at Kolla Diba Health Center, Dembia District in Northwest Ethiopia. Methods: A five years records of 827 tuberculosis patients at Kolla Diba Health Center was analyzed to assess tuberculosis treatment outcomes. Bivariate analyses using logistic regression model was used to analyze the  association between treatment outcome and potential predictor variables. Results:There were 827 (403 males, 424 females) with mean (SD) age of 31.1 (16.9) years study participants. Tuberculosis type was categorized as smear positive, 169 (20.4%), smear negative 278 (33.6%) and extrapulmonary case, 380 (45.9%). Treatment outcome was classified as successfully treated, 708 (85.6%), defaulted, 29 (3.5%), transferred out, 63 (7.6%) and died, 27 (3.3%). Patients aged 15 years or less had significantly high treatment success rate (aOR 4.576, P=0.004) followed by 35-44 years (aOR 3.829, P=0.003) and 25-34 years (aOR 3.669, P=0.002). Ninety (10.9%) patients were co-infected with HIV, which had more likely to die or transferred out compared to uninfected cases. Conclusion: Treatment success rate was fairly satisfactory. A high proportion of patients died or transferred out in HIV co-infected tuberculosis patients which is a serious public health concern that needs to be addressed right away.