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A Review on Analytical Methods for Estimation of Azelnidipine and Chlorthalidone in Pharmaceutical Dosage Form

Khushbu B. Patel, Riya V Barot

High blood pressure, also called hypertension, is a common condition that is characterized by having a higher amount of pressure in your blood vessels than normal. Hypertension (HT) is a very common disorder, particularly past middle age. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. For improvement activity of hypertension, Azelnidipine and Chlorthalidone newer combination in market,which is effective in Hypertension. This combination was developed to improve medication for Stage II Hypertension. Azelnidipine is Ca2+ channel blocker and chemically 3- [1- (Benzyldrylazetidin-3-yl] 5-isopropyl- 2- amino6methyl-4-(3- nitrophenyl)-1, 4- dihydropyridine-3,5dicarboxylate. Chlorthalidone is a diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions and Chemically 2-chloro-5-(1-hydroxy- 3-oxo- 2H-isoindol-1-yl) benzenesulfonamide. This Review focuses on recent development in analytical method development for Azelnidipine and Chlorthalidone, and there was no any method reported for this combination. It provides information about different analytical method development like UV spectrophotometry, HPLC, HPTLC, LC-MS methods reported for Azelnidipine and Chlorthalidone for individual and other drug combination.