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Antiangiogenic Therapy: Issues and Expectations

Takae Kataoka

The understanding that angiogenesis is essential for tumor growth and metastasis formation has led to a large effort to discover effective antiangiogenic compounds. It should be perceived that angiogenesis happens in pathologic cycles as well as in homeostasis. Physiologic angiogenesis is significant in multiplication, wound healing, menses, and vascular diseases like coronary artery and peripheral vascular diseases. Thus, as always, a balance must be maintained between limiting angiogenesis to the tumor and causing significant toxicity to
the host.