ISSN: 2381-8727



当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い

700 ジャーナル 15,000,000 人の読者 各ジャーナルは 25,000 人以上の読者を獲得


Anti-Inflammatory Effects of Bullatine A on LPS-Induced RAW264.7 Cells by Endoplasmic Reticulum Stress

Ren W, Zhou H, Xian-Ju H and Gao Y

Objective: Bullatine A (BLA), a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, antiinflammatory and anti-nociceptive effects. The mechanism underlying the anti-inflammatory effect was further examined using murine RAW264.7 macrophage cell lines in vitro.

Methods: The effects of BLA on cell apoptosis/death and endoplasmic reticulum (ER) stress in RAW264.7 cells induced by lipopolysaccharide (LPS) were examined. The effects of BLA on pro-inflammatory cytokines interleukin-6 (IL-6) as well as nitric oxide (NO), intracellular reactive oxygen species (ROS) and Ca2+ in RAW264.7 cells induced by LPS were examined.

Results: The results showed that BLA protected RAW 264.7 cells against apoptotic death induced by LPS via attenuated the production of pro-inflammatory factor interleukin-6 (IL-6), nitric oxide (NO), intracellular reactive oxygen species (ROS) and Ca2+ in LPS-treated RAW 264.7 cells.

Conclusion: The results demonstrated a significant anti-inflammatory and ER stress inhibitory properties of BLA. It also indicated that it may have beneficial therapeutic effects in the treatment of conditions associated with an overproduction of inflammatory cytokines, including pain, inflammation, cancer, and neurodegenerative diseases.