分析および生物分析技術ジャーナル

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Application of X-ray Fluorescence Spectrometers for Biopharmaceutical Forensics

Jessica P Mondia, Matthew Marrichi, Amr S Ali, Austen Ng and Maureen Lanan

In biopharmaceutical drug development and production, a portable energy dispersive x-ray fluorescence (EDXRF) spectrometer can be used for identification of foreign particles, investigation of discolored solutions, and improvement of process understanding. The spectrometer is a safe, small, robust, rapid, easy-to-use, multielemental diagnostic tool. Examples using the EDXRF for detecting metal composition in particulates, precipitants, liquids, and resins-with rapid resolution of investigations-are described.