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Argonaute-1 Machinery Silent Cancer Noises

Mondal T, Pal D, Bhadra MP, Bhadra U

Small non-coding RNA mediated that is micromanaging of global gene regulation was well established as fundamental principle in cell or tissue functions. To carry out, biological role small RNA needs a unique batch of protein family named Argonaute (AGO). The Argonaute proteins carry sophisticated and highly delicate interacting modules common for three specialized small RNAs, microRNA (miRNA), short interfering RNA (siRNA) and Piwi interacting RNA (piRNA). These RNA-proteins complexes are unique to coordinate silencing events in the genome. Recent works have made a novel role of AGO1 protein by extending its tentacle towards cancer monitoring pathways. It makes a constructive bridge between a direct and constructive link between cancer and RNAi (RNA interference) machinery. Apart from multifarious classical functions such as disruption of mRNA translation, decay, transcriptional regulation and splicing, we demonstrate a new concept to narrate the role of AGO1 proteins in different cancer regulatory pathways via microRNA- Argonaute circuit specifically.