臨床糖尿病ジャーナル

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Cardiovascular Disease and Premature Diabetes: Prevention and Risk Reduction Interventions based on Pathophysiology

Louis Ahern

Prediabetes is caused by pathophysiologic defects like insulin resistance, beta-cell dysfunction, and increased lipolysis, as well as an inadequate incretin effect and inflammation. Recent studies have shown that some people with prediabetes experience the long-term complications of diabetes; these confusions incorporate micro vascular and macro vascular messes. Last but not least, we discuss the implications of randomized control trials on the reduction of macro vascular risk and provide an overview of those studies that aim to stop the progression from prediabetes to diabetes.