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Charge Transfer Spectrophotometric Determination of Zolmitriptan in Pure and Dosage Forms

Ayman A Gouda, Ragaa El Sheikh and Rham M El- Azzazy

A facile, accurate, sensitive and validated spectrophotometric method for the determination of zolmitriptan (ZMT) in pure and dosage forms is described. The methods are based on the formation of charge transfer reactions between ZMT and chromogenic reagents 7,7,8,8-tetracyanoquinodimethane (TCNQ); p-chloranilic acid (P-CLA), quinalizarin (Quiz) and alizarin red S (ARS) producing charge transfer complexes which showed an absorption maximum at 840, 532, 554 and 534 nm for TCNQ, P-CLA, Quiz and ARS, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated. Beer’s law is obeyed in the concentration ranges 1.0-140 μg mL-1. The molar absorptivity, Sandell sensitivity, detection and quantification limits are also calculated. The correlation coefficient was ≥0.9991 (n=6) with a relative standard deviation (R.S.D.) of ≤1.01. The proposed methods were successfully applied for simultaneous determination of zolmitriptan in tablets with good accuracy and precision and without interferences from common additives and the validity assesses by applying the standard addition technique, which compared with those obtained using the reported method.