臨床および実験神経免疫学ジャーナル

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CIDP and CASPR1: A Rare Form of CIDP with Severe Neuropathic Pain

Martin MEM, Mazaro LP, Bandeira IP, de Medeiros WLG, Marrone CD, Nascimento O and Gonçalves MVM

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common inflammatory
neuropathy. Recently, autoantibodies against the Para nodal proteins are related to a kind of CIDP with a specific
clinical and manifestations. The Contactin associated protein-1 (CASPR1) is a cell-adhesion protein tightly
associated with Contactin in the Para nodal region and was identified as a possible antigen in inflammatory
neuropathies. Patients with CIDP who presents autoantibodies against CASPR1 have a distinct disease course.
Therefore, this study proposes that patients with CIDP should be tested to CASPR1.