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Comparative Study of Mean Platelet Volume (Mpv) in Type 2 Diabetes Patients with and without Foot Ulcers

Vinayaka NS, Dhruva H.M

Aim

Aim of the study was to compare MPV values of diabetic patients with and without foot ulcers and to study the relation of MPV with diabetic foot ulcers

Type of Study and Place of Study

The study was a prospective randomized study with selective sampling conducted at Kempegowda Institute of Medical Sciences, Bangalore for a period of 1 year from October 2018 to October 2019.

We collected MPV values of 150 patients with type 2 diabetes having non gangrenous DFU and compared them with MPV values of 150 type 2 diabetes patients without DFU after matching both the groups for age and sex. The following criteria were used for diagnosing diabetic foot ulcer: presence of systemic signs of infection, purulent discharge from the wound, and minimum two local signs of inflammation (erythema, warmth, edema, tenderness and induration).

Patients with DFU had an increased MPV value when compared to patients without DFU.

The underlying pro-inflammatory conditions causing diabetic foot ulcers have an influence on platelet volume. High MPV can be used as a biomarker for increased platelet activity resulting in more chromogenic episodes contributing to the formation of diabetic foot ulcers.