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Comparitive Study of Mean Platelet Value (Mpv) in Type 2 Diabetis Patients with and without Foot Ulcers

DR DHRUVA H M

Diabetes mellitus is a major health problem with

multiple micro and macrovascular complica-
tions.15% of the patients with diabetes suffer from

diabetic foot ulcers (DFU) during their lifetime. MPV

is a marker of platelet activation and function. In-
crease in MPV implies release of highly reactive

platelets and an increased risk of thrombosis and
atherosclerosis.
AIM: Aim of this study is to compare MPV value of
diabetic patients with and without foot ulcers and to
study the relation of diabetic foot ulcers with MPV
TYPE OF STUDY AND PLACE OF STUDY: The study

was a prospective study with selective sampling con-
ducted at KEMPEGOWDA INSTITUTE OF MEDICAL

SCIENCES ,Bangalore for a period of 1 year from OC-
TOBER 2018 to OCTOBER 2019

MATERIALS AND METHODS: We collected MPV val-
ues of 100 patients with type 2 diabetes having non

gangrenous DFU and compared them with MPV val-
ues of 100 type 2 diabetes patients without DFU

after matching both the groups for age and sex. The

following diagnostic criteria were used for diabet-
ic foot ulcer : presence of systemic signs of infec-
tion,purulent wound secretion,and atleast two local

signs of inflammation(erythema,warmth,edema,-
tenderness,induration) Diabetes mellitus (DM) is a

global pandemic. The increased Mean platelet vol-
ume (MPV) and its activity may play a role in the

development of vascular complications of this met-
abolic disorder. Metformin, the first-line therapy

for T2DM, the only drug demonstrated to reduce
cardiovascular complications in diabetic patients.
However, whether metformin can effectively prevent
thrombosis and its potential mechanism of action

is not fully understood. In this study, the first aim is
to determine whether there is a difference in MPV
between diabetics with and without macro- and

microvascular complications,compared to nondia-
betics. The second aim is to examine the effects of

metformine on MPV values in newly diagnosed type

2 DM patients on metformin monotherapy, and to in-
vestigate whether a correlation exists between MPV

and fasting blood glucose changes after and before
treatment. Methods: MPV values were measured
MPV in 87 newly diagnosed Type 2 diabetic patients,

25 insulin-dependent diabetic patients and 40 non-
diabetic control subjects, who had complete blood

count on venous blood sample taken into tripotas-
sium EDTA, using automatic blood counter (Diagon

D-Cell 60 CBC Eurup). The blood glucose level was
measured by glucose oxidase method. Statistical

evaluation was performed by SPSS for Windows sta-
tistics programme using linear regression analysis,

Student’s t, one way Anova, and Pearson correlation
tests. Results: MPV values were significantly higher
in Insulin- dependent T2DM group compared to the
newly diagnosed T2DM and control [9.7 ± 0.78 FL vs

8.52 ± 0.8 FL and 8.48 ± 0.9 FL ( P=0)], respective-
ly. Among the newly diagnosed patients MPV values

showed a low positive correlation with patient age (R
= 0.37, P= 0 ) but no correlation was with BMI ( R=-
0.001 ? P=0.99 ) and initial fasting plasma glucose (P=

0.111, R=0.172 ). MPV values were significantly re-
duced after 6-month metformin therapy [8.56±0.78

vs 8.18±0.70 (P<0.05)]. There were no statistically
significant associations of ?MPV with ?FBG levels

(beta coefficient=0.41,P=0.51) after metformin treat-
ment Conclusions: Our results showed that MPV val-
ues significantly higher in insulin- dependent T2DM

Euro Surgery 2020: Comparitive Study of Mean Platelet Value (Mpv) in Type 2 Diabetis
Patients with and without Foot Ulcers
DR DHRUVA H M
KEMPEGOWDA INSTITUTE OF MEDICAL SCIENCES,BANGALORE,INDIA.

2019
Vol. 4, Iss. 1 Extended Abstract

Medical Implants & Surgery

Note: This work is partly presented at 15th International Conference on Surgery and Anesthesia on August 10-11, 2020 held at London, UK