当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い
。オープンアクセスジャーナルはより多くの読者と引用を獲得
700 ジャーナル と 15,000,000 人の読者 各ジャーナルは 25,000 人以上の読者を獲得
Luis Dabul, Gerardo F Ferrer, Susanna Oh, Juan D Oms, Marcos A Sanchez-Gonzalez and Rhaisa Dumenigo
Sporadic creutzfelt-Jakob disease (sCJD) is a rare neurodegenerative disorder and the most common type of the prion diseases that affects humans. Its clinical manifestations are progressive dementia, myoclonus, visual or cerebellar disturbances, pyramidal dysfunction, and akinetic mutism. Laboratory findings include high levels of the 14-3-3 protein in cerebrospinal fluid and Electroencephalogram with periodic spikes at ≈ 1 Hz. We present a 51- year-old Hispanic woman with Hashimoto’s thyroiditis and a 1-year history of depression who developed rapidly progressive dementia. She required extensive diagnostic examinations and eventually was diagnosed with sCJD based on the World Health Organization diagnostic criteria. Real-time quaking-induced conversion (RT-QuIC) was positive, and thyroid peroxidase antibodies (TPO-AB) (2391 IU/ml) and 14-3-3 protein (3.8 ng/ml) were elevated. Her key findings included rapidly progressive dementia, ataxia, akinetic mutism, myoclonus, rigidity, visual disturbance, EEG (Electroencephalogram) with periodic sharp wave complexes at 1 Hz, and normal head CT scans. She progressively worsened and died 3 months after the onset. In sum, patients with CJD and Hashimoto’s thyroiditis should be (i) evaluated for autoimmune encephalitis, (ii) screened for a rise in TPO antibodies, and (iii) steroids administration should be considered as adjuvant therapy. This case illustrates a prion disease mediated immune system modulation which we believe is a potential underlying mechanism by which the 14-3-3 protein induces a steroid non-responsive autoimmune encephalitis.