ISSN: 2576-3881

サイトカイン生物学ジャーナル

オープンアクセス

当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い

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700 ジャーナル 15,000,000 人の読者 各ジャーナルは 25,000 人以上の読者を獲得

抽象的な

Cytokines and Infertility Influence of Cytokines and Local Inflammation in Women of Reproductive Age with Infertility

Alexander Trunov, Olga Obukhovа, Olga Gorbenko, Alevtina Shvayk and Liliya Trunovа

Objective: The objective of the study was to investigate concentrations of cytokines in peritoneal fluid from women with infertility and chronic infectious inflammation (CII) of reproductive system. Methods: 65 patients were included to the study: 50 patients were diagnosed with tubo-peritoneal infertility and CII of reproductive system in remission (CII was of bacterial origin); 15 patients were almost healthy age-matched woman. The concentrations of TNF-α, IL-4, IL-6, IL-10, monocyte chemo attractant protein-1 (MCP-1), IFN-γ and sVCAM-1 were measured in peritoneal fluid using enzyme-linked immunoassay. Results: Peritoneal fluid levels of TNF-α, IL-4, IL-6, IFN-γ, MCP-1, sVCAM-1 were significantly (p<0.05) higher in patients with infertility and CII compared to control group. The most significant difference (4.52 times) was found for IFN-γ concentrations. The concentration of IL-10 was not significantly differing between the groups. Conclusions: Local inflammation and activation of immune reactions with cytokines imbalance in patients with CII of reproductive system may play a role in the pathogenesis of tubo-peritoneal infertility.

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