薬学および生命科学における研究開発の国際ジャーナル

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DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE IN SYNTHETIC MIXTURE

Jani BR , Shah KV, Kapupara PP

The objective of the work is to develop UV spectroscopic method for simultaneous estimation of Dapagliflozin (DAPA) and Metformin hydrochloride (MET). This method involve solving of simultaneous equations based on measurement of absorbance at two wavelengths 225 nm and 237 nm. Both the drugs obey the Beer’s law in the concentration ranges employed for this method. Results of the methods were validated statistically. Novel, simple, sensitive, rapid, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of Dapagliflozin and Metformin hydrochloride. The method can be used to estimate the amount of Dapagliflozin and Metformin hydrochloride in mixture containing Dapagliflozin and Metformin hydrochloride.