薬学および生命科学における研究開発の国際ジャーナル

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DEVELOPMENT OF UV SPECTROPHOTOMETER METHOD OF CEFIXIM IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORMULATION

P.G.Bhange, A.P.Mehere, P.P.Katolkar

The simple, precise and economic UV methods have been developed for estimation of Cefixime in single component. Cefixime has the absorbance maxima in zero order spectra in 230 nm (method A). Method B applied was first order derivative for the analysis of Cefixime at 238.5 nm .Method C applied was area under curve in the wavelength range of 234-228 nm. Drug followed Beer-Lamberts law in the concentration range of 503.5 μg/ml for zero order, 10-60 μg for area under curve methods and first order derivative spectrum. The percentage recovery of Cefixim ranged from 98.05 to 101.075 in pharmaceutical dosage from result of analysis was validated statistically and by recovered study.