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Drug Metabolism Analysis using Liquid Chromatography-Mass Spectrometry (LC-MS)

Dr. Tyurin Michael

A pharmaceutical company is developing a new drug candidate for the treatment of a chronic disease. One of the critical steps in drug development understands how the drug is metabolized in the body, which can impact its efficacy and safety.

The company needs to analyze the metabolic pathways and identify metabolites produced when the drug is administered to living organisms.

They employ liquid chromatography-mass spectrometry (LC-MS), a powerful technique that combines separation capabilities of chromatography with the mass analysis capabilities of mass spectrometry. LC-MS allows them to separate and quantify different metabolites formed during drug metabolism.

By using LC-MS, the company identifies multiple metabolites produced in various organs, helping them understand the drug’s fate in the body. This knowledge guides further optimization of the drug’s structure and dosage, ensuring its effectiveness and safety.