当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い
。オープンアクセスジャーナルはより多くの読者と引用を獲得
700 ジャーナル と 15,000,000 人の読者 各ジャーナルは 25,000 人以上の読者を獲得
Maureen Ann Allen, Rosemary MacDougall, Matthew Murphy and Shelley Robertson
Background: Methadone is an effective long acting opioid analgesic used to manage nociceptive and neuropathic pain. Its unique lipophilic properties, absence of active metabolites and high volume of distribution allows for delivery routes that are distinct and innovative enabling patients uninterrupted and effective pain control in the last days of life. Objective: The purpose of this study was to explore the effectiveness and ease of administration of atomized methadone solution on the buccal mucosa when alternative routes including rectal and sublingual were seen as less desirable by families and health care providers in patients in the last days of life who could no longer swallow medications. Methods: The charts of thirty patients who took methadone solution at the end of life were retrospectively reviewed and data collected regarding the various transmucosal delivery routes used. Satisfaction questionnaires were completed by families and health care providers after death looking at the effectiveness of pain control and ease of administration when methadone solution was given sublingual, rectal or atomized on the buccal mucosa. Conclusion: All 30 patients remained on methadone solution until their death. Of the twenty-two patients (73%) who had methadone solution atomized buccally, one was switched to rectal administration due to bitter taste and one to sublingual due to family preference. All families surveyed reported that methadone solution was effective in controlling pain and easy to administer.