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EVALUATION OF ANTIDIABETIC, ANTIDYSLIPIDEMIC & HEPATOPROTECTIVE ACTIVITY OF HOMALIUM ZEYLANICUM IN ALLOXAN INDUCED DIABETIC RATS

Swathi Pothireddy, Saritha Chukka, Puligilla Shankaraiah

To evaluate the antidiabetic activity of Homalium zeylanicum stem bark extracts against Alloxan induced Diabetes mellitus. Materials and methods: Diabetes was induced in male Wistar rats by intraperitoneal injection of Alloxan (90mg/kg). Ethanol extract of Homalium zeylanicum stem bark were administered to the experimental rats (250mg and 500mg/kg, p.o. for 28 days). The antidiabetic & antidyslipidemic, effects of these extracts was evaluated by the assay of biochemical parameters (Blood glucose and lipid profiles, SGOT, SGPT) and histopathological studies of the liver. Results: In Ethanol extract-treated animals, the hyperglycemia by the Alloxan was controlled significantly by restoration of the levels of serum glucose, lipid profile and liver enzymes as compared to the normal and the standard drug Metformin treated groups. Histology of the liver sections of the animals treated with the extracts showed the presence of normal hepatics, absence of necrosis and fatty infiltration, which further evidenced the hepatoprotective activity. Conclusion: Ethanol extract of the stem bark of Homalium zeylanicum possesses significant antidiabetic, antidyslipidemic and hepatoprotective activity.