ジャーナル・オブ・オンコロジーの研究と治療

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Evaluation of the Prognostic Value of CRP Biomarkers and Procalcitonin to Predict Anastomotic Leak

Abbas Ghaheri

Background and objectives: Colorectal resection is used for various diseases, including (benign and malignant) neoplasms, intestinal inflammatory diseases and other benign diseases. One of the complications of colorectal resection is anastomotic leak. Some papers confirmed that predictive effects of CRP marker and procalcitonin are caused by anastomotic leak. This study aimed to evaluate the prognostic value of CRP marker and procalcitonin to anticipate anastomotic leak in patients undergoing elective colorectal resection surgery.

Materials and methods: This is a cross sectional study. Patients undergoing intestinal anastomosis were included in the study. WBC, T, CRP and procalcitonin were measured on the 3rd and 5th days after surgery. All patients with the increased level of CRP were followed up and underwent imaging in order to control the origin of infection and leak. SPSS 21 was used to analysis data.

Results: The study results indicated that 6 patients (5.8%) had anastomotic leak. It was found that procalcitonin (P=0.000), CRP on the 5th day (P=0.000), WBC on the 3rd and 5th days (P=0.011) (P=0.000) and body temperature on the 3rd and 5th days (P=0.058 P=0.000, respectively) with anastomosis have a significant relationship with anastomotic leak. However, no significant relationship was found between other variables, including demographic ones (age, gender) (P>0.05).

Conclusion: The results of the study showed that there is a relationship between procalcitonin, CRP, WBC and body temperature and anastomotic leak. Therefore, the patients can be followed up on the 3rd and 5th days with the above indexes and predicted the incidence of complications.