生化学と生理学: オープンアクセス

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Fatty Acid Binding Protein 4 And Fat Metabolic Markers Reacted To Human Catecholamines

Gongwen Wang

Fatty acid binding protein 4 (FABP4, also referred to as adipocyte FABP or aP2) may be a member of the cytosolic carboxylic acid binding protein family and highly expressed in adipocytes and macrophages [1]. FABPs bind to hydrophobic ligands like long chain fatty acids (FA) with high affinity. it's been proposed that biological function of FABPs is trafficking of FA to subcellular compartments. Clinical and animal-based studies have demonstrated that FABP4 has a crucial role in obesity-related metabolic diseases like insulin resistance, type 2 diabetes, hepatosteatosis and atherosclerosis. Recently, FABP4 has also been introduced as a fat-derived circulating protein. Serum FABP4 levels are strongly correlated with adiposity while FABP4 is eliminated from the circulation mainly by renal clearance, Secretion of FABP4 from adipocytes is enhanced by lipolysis,