薬学および生命科学における研究開発の国際ジャーナル

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FLOATING DRUG DELIVERY SYSTEM : An Overview

Anupama Sarawade, M. P. Ratnaparkhi, Shilpa Chaudhari

Floating drug delivery systems (FDDS) was to organize the recently focus on the principalmechanism of floatation to achieve gastric retention time. The recent developments of FDDS including thephysiological and formulation variables affecting gastric retention, approaches to design floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying ofdosage forms is an extremely variable process and ability to prolong and control the gastric emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Gastroretentive systems can remain in the gastric region for several hours for significantly prolong residence time of drugs by which improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment.. The present review addresses briefly about the floating drug delivery systems.