ジャーナル・オブ・オンコロジーの研究と治療

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Helicobacter pylori Infection and Gallbladder Diseases: A Mini-Review

Mohammad Bagher Jahantab, Reza Hosseinpour, Cambyz Irajie, Amir Abbas Safaripour, Mohammad Javad Yavari Barhaghtalab

Helicobacter pylori (H. pylori) are recognized as one of the most common chronic bacterial infections worldwide. It’s proved to be the main pathogenic agent in chronic gastritis, peptic ulcer, and gastric cancer, as well as the proposed etiology in diseases of the organs other than the stomach and duodenum like liver, biliary system, heart and vascular system, and skin. Different studies have suggested bacterial infection with H. pylori can also be involved in the pathogenesis of gallbladder diseases. If such association is proven, the incidence of gallbladder diseases and their consequent morbidity and mortality can be reduced significantly following the treatment of H. pylori infection. Therefore, in this mini-review, we aimed to discuss shortly about the association of H. pylori infection in gallbladder diseases, such as chronic cholecystitis, cholelithiasis and gall bladder cancer. Our study shows that H. pylori infection in the gallbladder may be one of the etiological factors leading to the gallbladder diseases. The precise mechanism requires further verifications.