分析および生物分析技術ジャーナル

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Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar- Based Amphipathic Compounds

Zhirong Xin, Binbin Du, Yanming Wang, Shengxu Qian, Weijia Li, Yuan Gao, Miao Sun, Shifang Luan and Jinghua Yin

Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing polymer surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased.