薬学および生命科学における研究開発の国際ジャーナル

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In Vivo Anti-Inflammatory Activity Of Pajanelia Longifoliabark Extracts

Parameshwarappa Latha Kotehal

Introduction:

Screening of anti-inflammatory and anti-diabetic properties of Pajanelia longifolia bark extract with the preliminary phytochemical profile of the extracts has been carried out in this part of work. The dried plant material was subject to extraction by using Soxhlet apparatus. The different solvent namely pet ether, chloroform and methanol were used for the extraction. All the crude extracts were subject for anti-inflammatory activity by using carrageenan-induced paw edema method.The toxicity and phytochemical screenings were done using the standard procedure. Different phytoconstituents namely Alkaloids, flavonoids, phytosterols, phenolic compounds, glycosides carbohydrates, proteins, gums and amino acids have been examined by standard phytochemical tests. The acute toxicity study of various extracts of Pajanelia longifolia was conducted at the dosage of 2000 mg kg^-1 body weight for anti-inflammatory activity. Among all the extracts, chloroform extract showed a significant decrease in the inflammation, when compared with the standard.

Conclusion:

The bark extracts of Pajanelialongifolia (300 mg/kg; p.o) administered 30 min before the injection of carrageenan caused a significant (P<0.01) and dose dependent inhibition of increase in paw edema. In the carrageenan test, the maximum inhibition elicited by the chloroform extract (45.28%) was comparable to that of indomethacin (10 mg/kg; p.o; 67.92%). Pet-ether

extract showed a negligible inhibition while methanol extract showed a moderate inhibition of increase in paw edema in rats when compared to standard Indomethacin.