臨床薬理学および生物薬剤学

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In vivo Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation

Safila Naveed, Najma Sultana, Saeed Arayne M, Rakhshinda Siddiqui and Moona Mehboob

Both antihypertensive and non steroidal anti-inflammatory drugs are frequently prescribed together since hypertension and co-existing musculoskeletal problems are two of the frequent conditions. In vivo interaction studies of ACE inhibitors (enalapril, captopril and lisinopril) were carried out with commonly used NSAIDs (diclofenac sodium and mefenamic acid) in carrageenan induced inflammation in rats (CII) to check the anti-inflammatory response of NSAIDs in such cases. Edema rate and percentage reduction were calculated and data was analyzed by one way analysis of variance using SPSS INC. software. Tukey’s post-hoc test was conducted to determine group means differences taking significant level p<0.05 and p<0.005 highly significant.