肥満と減量療法のジャーナル

抽象的な

Ketohexokinase (KHK) Physiology and Treatments in Obesity and Fructose Metabolism

Yunfei Li*, Guodong Zhu

Obesity is defined as a disproportionate body weight for height with excessive accumulation of subcutaneous and visceral adipose tissue. Over the past decades, number of obesity patient multiplied. Obesity has turned into a medical issue worldwide. According to a survey from WHO in 2016, more than 1.9 billion adults were overweight or obese. By 2030, there will be 3.3 billion people who have a BMI greater than 25 kg/m2. Obesity is associated with the development of type 2 diabetes mellitus, cardiovascular infection, systemic inflammation and particular kinds of cancer. Some of these obesity-associated diseases belong to metabolic syndrome. In recent years, several factors leading to obesity have been disclosed. Among these, excessive intake of fructose may contribute heavily to the epidemic of obesity, type 2 diabetes mellitus, Non-Alcoholic Fatty Liver Disease (NAFLD) and other metabolic disease. Herein, we review the biochemistry, physiology of fructose metabolism and generalize the current treatment progress. As a sim