妊娠と小児の健康に関するジャーナル

抽象的な

Maternal Near Miss and Still birth in developing countries: A Systematic Review with Meta-Analysis

Ewnetu Firdawek, Alemayehu Worku and Mesganaw Fantahun

Background: Maternal near miss during pregnancy and delivery are known to increase the odds of still birth. Although the available few studies suggested the association between maternal near miss and still birth, pooled effect of individual studies is not yet known for developing countries. Hence the aim of the Meta-analysis was to quantify the association between maternal near miss and still birth from studies conducted in developing countries.

Method: Electronic data bases like MEDLINE and Embase were used to search for relevant articles. Observational studies which were published in English language, irrespective of publication status were considered. The methodological quality of the studies included in the current review was done using the Newcastle Ottawa assessment scale and British Sociological Association Medical Sociology Group quality indicators. Pooled estimate along with 95% CI were calculated using random effect model. I2 statistics were used to test for heterogeneity. Forest plot were used to present findings. Egger’s and Begg’s test was done to check for presence of publication bias.

Result: Search of electronic data bases identified 265 studies of which five were included for the final analysis. Majority of the studies have a high methodological quality. The result of pooled estimate showed that the odds of still birth was higher in women who developed maternal near miss than those who deliver without complications (Pooled OR=4.67, 95% CI [2.91-7.47], I2=85.0%). Sub group analysis based on the design of the studies indicated that variation in the design was one of the factors responsible for the observed heterogeneity. The presence of publication bias was not observed from Begg’s and Egger’s test. (Begg’s Test p=0.462 and Egger’s test p=0.637)

Conclusion: The study revealed that the odds of still birth are higher in women who developed maternal near miss complications as compared to women without any complications. Hence this evidence will help policy makers in developing countries to design appropriate interventions that will enhance quality of obstetric care for women during pregnancy, delivery and after delivery so as to save the life of babies born from these women.