ISSN: 2476-2024

病理診断: オープンアクセス


当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い

700 ジャーナル 15,000,000 人の読者 各ジャーナルは 25,000 人以上の読者を獲得


Methylation Level of ASC/TMS1 and MYD88 Genes in Healthy Larynx and Laryngeal Carcinoma Tissue

Lana Kovač Bilić1 , Jelena Knežević2 , Maja Šutić2 , Srećko Branica1, Krsto Dawidowsky1 and Mario Bilić1* 

Abstract Background: There are no biomarkers for diagnosis, prognosis and treatment of patients with laryngeal carcinoma. Methylation changes of ASC/TMS1 and MYD88 genes, in healthy and cancer tissue, might be related with development and progression of cancer. The study explored is there a difference in gene’s methylation in healthy and tumor tissue and does it correlate with protein expression. Results: The total of 36 patients were enrolled in the study. Methylation of bisulphite converted DNA was quantified by pyrosequencing in fresh frozen cancer and adjacent non-malignant tissues. The overall methylation of MYD88 gene is significantly higher in healthy tissue and this finding correlates with protein expression and the overall methylation of ASC/TMS1 gene is unchanged but the protein expression of ASC/TMS1 is significantly higher in cancer. Conclusion: The methylation status of the ASC/TMS1 and MYD88 genes are promising prognostic biomarker candidates and may lead to earlier detection of laryngeal cancer.