臨床糖尿病ジャーナル

抽象的な

Microalbuminuria and Single Nucleotide Polymorphisms Linked to Prediabetes

Alexander Abse

In the pathogenesis of diabetic micro vascular complications represented by Microalbuminuria, increased glycaemic exposure is crucial even below the diagnostic criteria for diabetes mellitus. In any case, there is restricted proof in regards to which single nucleotide polymorphisms are related with prediabetes and whether hereditary inclination to prediabetes is connected with Microalbuminuria, particularly in everyone. Our goal was to respond to these questions. In the Korean Genome and Epidemiology Study, we separately conducted a genomewide association study on two population-based cohorts, Ansung and Ansan. After the initial GWAS on the Ansung cohort, a replication study on the Ansan cohort followed. Either the prediabetes group or the control group comprised all native Korean participants who did not have a significant medical condition. Two susceptibility loci for prediabetes were found in the GWAS. in another gene and the GCK gene. Microalbuminuria increased in this genetically determined form of prediabetes when GCK variations were used as a model. Multiple logistic regression analyses revealed that age, gender, smoking history, systolic blood pressure, waist circumference, and serum triglyceride levels had no effect on the association between fasting plasma glucose concentration and micro albuminuria.