ISSN: 2476-2024

病理診断: オープンアクセス

オープンアクセス

当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い

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Micro-MRI-based Detection of Tissue Damage in the Liver, Pancreas, and Kidney during the Early Phases of an LPS and D-Galactosamine-Induced Hepatic Injury Model in Mice

Nodoka Nago, Misao Yoneda, Samuel Darkwah, Eiji Kawamoto, Eun Jeong Park and Motomu Shimaoka

How tissue injuries progress among organs during LPS-induced fulminant hepatic failure remains to be elucidated, especially during the very acute phase of small animal models. We have addressed this problem in LPS/D-galactosamine-induced fulminant hepatitis by using sequential micro-MRI scanning. Analysis of T2-weighted MRI signal intensities detected tissue injury in the liver during the early phase (as early as the 3 h timepoint), at which point histological examination revealed only minor morphological changes in hepatic tissues. In the pancreas, increases in the T2-weighted signals were made readily apparent by the pancreatic edema formation that was determined by histological examination. Only minimal pathologies were observed in the renal cortex based on micro-MRI and histological examination. The results of this study have demonstrated the distinct temporal changes that occur in the liver and injured pancreatic acinar cells during the very acute phase of LPS-induced hepatitis.

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