粘膜免疫学研究ジャーナル

抽象的な

Mucosal Microbiota: A Key Player in Human Health and Disease

Shia R

The human body is home to trillions of microorganisms, collectively known as the microbiota, which reside on various mucosal surfaces, including the gastrointestinal, respiratory, and genitourinary tracts. The mucosal microbiota plays a critical role in maintaining human health and has a profound impact on immune function, nutrient metabolism, and overall physiological homeostasis. This abstract aims to provide an overview of the mucosal microbiota and its significance in human health and disease. It begins by discussing the composition and diversity of the mucosal microbiota, highlighting the various bacterial, viral, and fungal species that colonize these surfaces. The mechanisms governing the establishment and maintenance of the mucosal microbiota are explored, including early-life factors, environmental influences, and host-microbe interactions. The functional roles of the mucosal microbiota are examined, emphasizing its involvement in immune modulation and protection against pathogens. The complex interactions between the microbiota and the host immune system are elucidated, including the development of immune tolerance, stimulation of innate and adaptive immune responses, and the potential impact on immune-related disorders. Furthermore, this abstract delves into the crucial roles of the mucosal microbiota in nutrient metabolism and energy extraction. The microbiota contributes to the breakdown of complex dietary components, such as fiber, and the production of short-chain fatty acids that are beneficial for host health. Dysbiosis, characterized by alterations in the mucosal microbiota composition and function, is associated with various diseases, including inflammatory bowel disease, asthma, allergies, and urogenital infections. Finally, emerging research on therapeutic interventions targeting the mucosal microbiota is discussed. Strategies such as probiotics, prebiotics, fecal microbiota transplantation, and targeted antimicrobial therapies hold promise for modulating the mucosal microbiota and improving health outcomes in specific disease conditions.