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Naturally Occurring Enzyme Inhibitors: A Smart Way to Fight against Micro- Inflammation in Human Gut

Rabail Razi, Zainab Mir, Rimsha Dilshad, Fatima Tuz Zahra and Atif AB*

Human body is a reservoir for microorganisms, the majority of which resides in the gastrointestinal tract. The diverse micro biota helps to speed up the metabolic processes such as digestion along with providing protection against infections. A balanced diet plays major role in maintaining the balance of gut flora, which could otherwise lead to Dysbiosis. Dysbiosis is an inflammatory condition caused by the over production of bacterial nitroreductase, azoreductase and beta-glucuronidase enzymes. In the following article the active sites of all three enzymes along with their inhibitors were studied. One inhibitor against nitroreuctase, two against azoreductase and three against beta-glucuronidase were selected and docking was done. The inhibitors blocked the enzymes activity. These inhibitors can be obtained from natural food sources to attain a balanced microbial flora resulting in a better metabolism.