臨床薬理学および生物薬剤学

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One Hormone, Two Actions: Glucocorticoids' Anti- and Pro-Inflammatory Effects

Brian Berridge

The medicinal drug activity of glucocorticoids is attributed to the repression of pro-inflammatory genes through signal transduction by their steroid receptor, the hormone receptor (GR). The mechanisms modulating the proinflammatory effects of glucocorticoids aren't well understood. During this review, we tend to discuss recent findings that offer insights into the mechanism by that GR sign will play a twin role within the regulation of the immune reaction. We tend to theorize that these apparently opposite processes square measure operating along to organize the system to reply to a agent (pro-inflammatory effects) and after restore physiological state (anti-inflammatory effects). Finally, we tend to propose that determinant the mechanisms that underlie the tissue-specific effects of hormones can offer a wonderful tool to develop a lot of economical and selective glucocorticoid therapies.