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Outline about Biological and Chemical Coordinations of Some Sulphonyl Drugs

MG Abd El-Wahed, Mohamed Y El-Sayed, Samy M El-Megharbel,Yasmin M Zahran, and Moamen S Refat

During the past two decades, considerable attention has been paid to the chemistry of the metal-drug interactions. It has been suggested that the presence of transition or non-transition metal ions in biological fluids could have a significant effect on therapeutic action of drugs. The successful synthesis, interpretations and application of novel metal complexes can have a great impact on all areas of chemistry and biology. It’s worthwhile to study the synthesis and characterizations of some complexes containing nucleus of sulfonylurea’s which have a widely known concerning the biological application in our life. As yet from the literature survey, little information is available about the metal complexation of sulfonylureas compounds, which are effective as coordinating ligands with the functional sites like sulfon-amide group. In view of the biological, physico-chemical properties and industrial importance of these ligands and their metal complexes, the aim of the present work is to shed light on the understanding about the nature of interaction and chelation between metal ions and these moieties, investigation of the physico-chemical properties of the ligand and their metal complexes and screening of the ligands and their metal complexes for their biological activity. Sulfonylureas are the most commonly prescribed diabetes medicines. They are inexpensive and have few side effects. These medicines help your body make insulin. They can be taken alone or with metformin, an alpha-glucosidase inhibitor, pioglitazone or insulin. If you’re allergic to sulfa, you can’t take a sulfonylurea.