臨床および実験神経免疫学ジャーナル

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Polyglandular Type III C Syndrome Associated with Double-Seronegative Myasthenia Gravis

de Araujo T  , Giacomet MDM, de Freitas LS and Gonçalves MVM

The neuroimmunologic diseases are a challenge to health services. We described the evolution of MG in the patient presented as proximal weakness, fatigue, chest pain, ptosis, arthralgia, diplopia and dysphonia. Besides that, the patient presented Systemic Lupus Erythematosus (SLE), positivity/reagent for antinuclear antibody (ANA), anti-thyroid peroxidase antibodies (anti-TPO antibodies) and anti-glutamic acid decarboxylase (anti-GAD). Because of the other comorbidities, the hypothesis of the Polyglandular Autoimmune Syndrome (PAS) III was made, represented by the combination of a clinical diagnosis of an autoimmune thyroiditis with Diabetes Mellitus type 1 (DM1).