薬学および生命科学における研究開発の国際ジャーナル

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Propranolol application in gynecological disease: review

Salwa Samir Anter

Propranolol  is  β-adrenergic  receptor  blocker  with  reported  antioxidant effect  and anti-inflammatory  action , is  used in treatment of  the hypertension mainly, and main benefit in treatment patients with angina  pectoris or  myocardial infarction, add to role in central nervous system diseases as migraines and  anxiety  disorders,  and  tremor  but rarely used in gynecology  field  in  spite of  many  action  either  by  beta  receptor  block  or other  mechanisms it acts with, such as  anti _inflammatory, anticancer, antioxidant activity,pro_poptosis, and wound healing,

In this review, we have  discussed the various aspects of propranolol that can be applied in clinical gynecology in number of ways such as  local contraceptive, in the  treatment  of  Vulovaginitis  by  affected main criteria of Trichomonas and Guardia lamblia ,which is motility ,propranolol inhibited motility of both organism and consequence inhibition of the growth of both organism, for the treatment of genital hemangioma,We have also shed some light on experimental studies _ such as its effect on polycystic  ovary  and endometriosis

Introduction:

Propranolol  is  a drug with    beta  blocker  effect and used clinical in   treated  hypertension  Thyrotoxicosis,  and recent in capillary hemangiomas, anxiety, and essential tremors.(1)  but  clinical  applications  in  gynecology is  limited  and  route  of  administration  oral  route, injection  but  what  about  vagina  route  is  used  only as  spermicidal  effect