整形外科腫瘍学ジャーナル

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Recurrent Pelvic Aneurysmal Bone Cyst Treated With Doxycycline: A Case Report

Dr. T Kyle Summers MD*1, Austin Bettridge MSIV2 and Dr. Prasit Nimityongskul MD3

Background: Aneurysmal bone cysts (ABCs) are locally aggressive, non-cancerous bone lesions that are rare, most commonly occur in children (75% of patients are < 20 yrs 1), and typically continue to spread until treated. They have a high risk of recurrence [1].

Methods: We present an 11-year-old female with a recurrent ABC of the pelvis, involving the right pubic ramus, ischium and medial wall of the acetabulum. She was treated initially with curettage and bone grafting but was discovered to have recurred at two-year follow-up. She was successfully treated with repeat curettage with iliac bone grafting and doxycycline as a sclerosing agent.

Results: At two and three-month follow up visits the patient continues to ambulate well, and radiographs demonstrate healing with successful graft incorporation and no sign of recurrence.

Conclusion: At the time of this publication, there were no reports detailing the use of doxycycline as a sclerosing agent for recurrent pelvic ABCs as extensive as the case presented here. However, doxycycline has been recently reported as efficacious in the treatment of other recurrent ABCs, primarily through percutaneous administration.