薬学および生命科学における研究開発の国際ジャーナル

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RELATIONSHIP OF C-REACTIVE PROTEIN, URIC ACID, LIPID PROFILE WITH TYPE 2 DIABETES MELLITUS IN TRINIDAD

B S Nayak, D Brennen, S Narine, A Rampersad, J Sinanan, R Dilbar, R Singh, S Khan, S Ali, V Lowe, S Maharaj

Objectives: To examine the relationship of C-reactive protein (CRP), lipid profile, uric acid, age and gender in subjects with type 2 diabetes and to determine whether there are links between these variables and disease manifestations. Methods and materials: A retrospective study comprised 206 patients from two major hospitals of Trinidad and Tobago with (67) and without (139) diabetes. Results: There were 117 females (57%) and the majority of participants were Indo-Trinidadians (60.7%). The diabetic subjects had elevated C-reactive protein (0.95 mg/L±1.6), uric acid (6.0 ± 2.1), triglycerides (155.53 ± 82.14) and LDL cholesterol (123.35± 51.84) when compared to non-diabetic population with CRP (0.48 mg/L± 0.56) uric acid (5.66 ± 2.47), triglycerides (138.39 ±72.22) and LDL-cholesterol (117.36 ± 35.50). The incidence of diabetes showed a normal distribution, increasing with age and peaking in the 50-59 age groups. An association was observed between uric acid and lipid profile in diabetic subjects. After adjustment for age and gender, in the diabetic population with an elevated CRP, a direct relationship was observed between uric acid and cholesterol levels as the same patients show marked elevations in both categories. Conclusions: Our study did not found any useful predictors for CRP and diabetic subjects. The CRP levels within the participants fluctuated to a great extent and showed no correlation with increased uric acid, lipid profile or diabetic status.