バイオテクノロジーとバイオマテリアル

抽象的な

Relative Study of Different Brands of Loratadine Available in Local Market of Karachi

Alveena Sadiq*

Loratidine, Histamine H1 receptor is one in all the popular antagonists, non-sedating used for the treatment of allergic rhinitis, urticarial and transient alleviation of signs caused by hay fever. Loratidine blocking the release and action of histamine, a natural substance within the body that is released by means of immune system at some point of an allergic reaction. Many products of loratadine are marketed which makes it difficult to pick safe, effective, and economic one. The purpose of this study is to establish similarity amongst different brands of loratadine tablets to be had in nearby market of Karachi, Pakistan. In this study three brands of loratadine (10mg) were decided on and evaluated. Six quality control parameters: weight variation test, hardness check, thickness, friability, disintegration test and dissolution test were carried out which  indicated by USP. Dissolution Test performed by using paddle method (USP 2) in 900 ml of 0.1N HCl at 50 rpm. The physicochemical parameter of loratidine did not shows any variation. Results shows that selected brands comply with in acceptance limits for weight variation, hardness, thickness, friability, disintegration and dissolution,  disintegration time for all brands was in 15 minutes complying with the USP standards. From this study we concluded that all available brands of loratidine have same physiochemical parameter within the specified quality control range and may be interchange if located any non-compliance due to price issue.