ジャーナル・オブ・オンコロジーの研究と治療

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Role of Mitochondrial Zinc in Progression of Prostate Cancer: A Diagnostic Biomarker for Prostate Cancer

Rashmi Rana, Ravi Kant, Nirmal Kumar Ganguly

Prostate gland is a complex organ found in men, having different components which are named as peripheral, central zone and a periurethral region. Biomarkers development for screening and detection of prostate cancer proved crucial in its easy and early management. Mitochondrial Zinc plays a crucial role in progression of prostate cancer. Peripheral zone of prostate gland has uncommon feature of zinc accumulation which result in collection and secretion of high level of citrate along with components of semen. High amount of zinc inhibit the action of m-aconitase which in turn inhibits citrate oxidation. This review describes the metabolic zinc relationships found in normal and malignant prostate. In this review paper, we will also review the current knowledge on prostate cancer biomarkers such as PSA, PCA3, TMPRSS2-ERG, α-Methylacyl–coenzyme a racemase. Validation of existing biomarkers is essential and future research should focus in validation of existing biomarkers along with discovery of new biomarkers