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The Cytotoxic efficacy of aliphatic aromatic copolyesters containing chalcone moiety against MCF7 breast cancer cell lines

S. JASMINE, D. REUBEN JONATHAN , J. SIDHARTHAN , D. ROOPSINGH

One of the most obstinate diseases in human beings, with uncontrollable growth and spreading of abnormal cells is cancer. Cancers like breast cancer, blood cancer, liver cancer, lung cancer, brain cancer, colon cancer, prostate cancer, cervical cancer and ovarian cancer etc. play a vital role in the mortality rate of humans. According to WHO, due to cancer, worldwide 9.6 million people were died in the year 2018 and it is expected to affect 22 million by 2030. American Cancer Society survey of 2015 reports that, breast cancer ranks second in the death of women. Despite treatments like surgery, radiation, chemotherapy, hormone therapy, immune therapy, targeted therapy, have reduced the risks of lower lifespan, number of deaths in the world population are always on the rise due to serious side effects and multidrug resisting cancer cells . Therefore, a greater need of anticancer agents with low toxicity and targeted therapies are necessary. Apart from cancer, contagious diseases like SARS and COVID 19 have consumed more lives in short time world over. It is also feared that the humans along with pets are going to encounter epidemics and pandemics in not so distant future.