栄養科学研究ジャーナル

抽象的な

The Effect of 28 Days of Beta-alanine Supplementation on Exercise Capacity and Insulin Sensitivity in Individuals with Type 2 Diabetes Mellitus: A Randomised, Double-blind and Placebo-controlled Pilot Trial

Nealon RS, Sukala WR, Coutts RA and Zhou S

Objective: To determine the effects of 28 days of BA supplementation on exercise capacity as measured by time to volitional failure during an incremental treadmill test in individuals with T2DM. Methods: Participants undertook a modified Naughton treadmill test to assess exercise capacity and a fasting blood test before and after the supplementation period. Participants consumed four grams of BA (n=7) per day or the equivalent amount of maltodextrin (n=5) for 28 days and maintained their lifestyle habits during the supplementation period. Results: Twenty-eight days of BA supplementation significantly increased the time to volitional failure during the treadmill exercise test by m=135.2, SD=(± 81.3) seconds (21%), p=0.001, as detected by general linear model analysis with repeated measures. There was significant interaction of pre to post by group in fasting blood glucose, p=0.046. A strong negative correlation was found between the changes in the time to volitional failure during exercise testing and the changes in fasting blood glucose in the beta-alanine treatment group, r=− 0.92, p<0.01. Conclusion: This study has provided new evidence that BA supplementation can increase exercise capacity in individuals with T2DM.