ジャーナル・オブ・オンコロジーの研究と治療

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The Implications of SFRP2 Gene Hypermethylation in Colorectal Cancer

Shayista Ahmad, Gowhar Rashid, Madiha Niyaz, Syed Nisar, Syed Mudassar

Background: The Wnt pathway is stimulated by the DNA hypermethylation of SFRP2, which inhibits gene activity, downregulates the gene expression and promotes CRC.

Objectives: This study aims to assess the prognostic impact of hypermethylation of SFRP2 in colorectal cancer.

Methodology: The research used twenty (20) blood samples from patients with colorectal cancer detected at Sher-I-Kashmir institute of medical sciences as well as thirty (30) patients with histologically confirmed colorectal cancer who underwent surgical excision in the department of general surgery. Methylation Specific PCR (MSP) was employed to assess SFRP2 methylation and the results were correlated with several investigated clinicopathological characteristics.

Results: Our results showed that SFRP2 methylation levels are significantly present in tumor tissues and blood samples as compared to normal counterparts.

Conclusion: We infer that the hypermethylation of the SFRP2 promoter in colorectal tumors may contribute to the development of cancer in normal colon and rectum cells.