移植レポート : オープンアクセス


当社グループは 3,000 以上の世界的なカンファレンスシリーズ 米国、ヨーロッパ、世界中で毎年イベントが開催されます。 1,000 のより科学的な学会からの支援を受けたアジア および 700 以上の オープン アクセスを発行ジャーナルには 50,000 人以上の著名人が掲載されており、科学者が編集委員として名高い

700 ジャーナル 15,000,000 人の読者 各ジャーナルは 25,000 人以上の読者を獲得


The Importance of Presymptomatic State and the Rapid Transition from Consultation to Transplantation are Highlighted in This Study for Both Early and Late Difficulties

Jaap Jan Boelens

Leukodystrophies (LD) are ruinous inherited diseases leading to rapid-fire neurological deterioration and unseasonable death. Hematopoietic stem cell transplantation (HSCT) can halt complaint progression for named LD. Cord blood is a common patron source for transplantation of these cases because it's fleetly available and can be used without full HLA matching. Still, precise recommendations allowing care providers to identify cases that profit from HSCT are lacking. In this study, we define threat factors and describe the early and late issues of 169 cases with globoid cell leukodystrophy-linked adrenoleukodystrophy, and metachromatic leukodystrophy witnessing cord blood transplantation (CBT) at a European Society for Blood and Gist Transplantation center or at Duke University Medical Center from 1996 to 2013. Factors associated with advanced overall survival( zilches) included presymptomatic status( 77 vs 49; P = .006), well- matched( ≤ 1 HLA mismatch) CB units( 71 vs 54; P = .009), and performance status( PS) of> 80 vs< 60 or 60 to 80( 69 vs 32 and 55, independently; P = .003). For cases with PS ≤ 60(n = 20) or 60 to 80(n = 24) pre-CBT, only 4(9) showed enhancement. Overall, encouraging zilches was set up for LD cases after CBT, especially for those who are presymptomatic before CBT and entered adequately cured grafts. Beforehand identification and fast referral to a technical center may lead to earlier treatment and, latterly, to bettered outgrowth