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The Role of Human Leukocyte Antigen Typing in Libyan Patients with Chronic Periodontitis

Daeki AO, Maroof F and Ben-Darif E

Background: Periodontitis is an inflammation of gums and teeth bone that caused by certain bacterial normal flora in the mouth leading to destroy periodontal tissues. Human leukocyte antigen (HLA) gene has an important role in determinant the susceptibility and progression of periodontitis in human to facilitate diagnostic and therapeutic value. This study was performed to find out the association between HLA classes I and II genes with chronic
periodontitis.
Material and methods: A total of 114 individuals (60 patients with chronic periodontitis and 54 controls) were collected from Tripoli Central Hospital. All study population was examined clinically using Ramfjord chart for diagnosis the periodontitis cases and subsequently were analyzed their blood samples using specific-sequence oligonucleotide PCR (SSO-PCR) assay for typing various HLA loci.
Results: Distribution of different HLA-B and HLA-A loci among patients and control individuals were statistically significant in the HLA-B45 and HLA-A30 alleles, P<0.03 and P<0.04, respectively. Furthermore, statistically significant differences were observed between patients and controls in HLA-DRB114 and HLA-DRB5 alleles, P<0.00 and P<0.00, respectively. Generally, there is non-significant differences were observed in HLA-DRB3, HLA-DRB4
loci.
Conclusion: The HLA-B45 and HLA-A30 alleles may represent as risk factors for chronic periodontitis cases in Libyan population, whereas HLA-DRB114 and HLA-DRB5 may indicate to protective factors for chronic periodontitis among Libyan populations.