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The Second Messengers Ca²⁺ and cAMP as Potential Therapeutic Targets for the Control of Cancer Progression

Paolo Ruggero Errante, Francisco Sandro Menezes-Rodrigues, Alberto Andrade Leite, Afonso Caricati-Neto and Leandro Bueno Bergantin

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca²⁺ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment.