分析および生物分析技術ジャーナル

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Urinary Excretion and Renal Clearance of Allopurinol in Female Gout Patients

Bilal Ahmed, Imtiaz SohailTahira Iqbal, Abdual Ghaffar and Bushra Munir

Drugs are excreted from the human body either unchanged or as metabolite. Gout is treated with allopurinol drug which lowers uric acid level in humans. Xanthine oxidase activity is inhibited with allopurinol which converts hypo-Xanthine and xanthine into uric acid. In case of kidney impairment monitoring of allopurinol drug metabolism was important option for optimization of allopurinol. Allopurinol level was measured in human serum and urine of gout patients after oral intake of allopurinol by using HPLC (high performance liquid chromatography). In female gout patients (n=10) allopurinol was measured in blood and urine samples at 254 nm after taking 300 mg drug. Serum uric acid level, renal function test (RFTs) and urine complete examination was checked before and after oral administration of allopurinol. Statistically results were analyzed and explained.